The Effects of Cannabidiol on Cerebral Blood Flow

The primary aim of this research paper was to investigate how CBD influences cerebral blood flow (CBF) in regions involved in memory processing. It was conducted under a randomised, crossover, double-blind design in which 15 healthy participants were administered CBD or a placebo on separate days. Regional CBF was measured at rest using arterial spin labelling 3h after drug ingestion. Working memory was assessed with the digit span (forward, backward) and n-back (0-back, 1-back, 2-back) tasks, and a prose recall task was used (immediate and delayed) to assess episodic memory.

CBD increased CBF in the hippocampus (mean (95% confidence intervals) = 15.00 (5.78–24.21) mL/100 g/min, t14 = 3.489, Cohen’s d = 0.75, p = 0.004). There were no differences in memory task performance, but there was a significant correlation whereby greater CBD-induced increases in orbitofrontal CBF were associated with reduced reaction time on the 2-back working memory task ( r= −0.73, p = 0.005).

This may be the first study to find that acute CBD increases CBF in the hippocampus. This supports the view that CBD has region-specific haemodynamic effects in the human brain. If replicated, the finding that acute CBD increases CBF in the hippocampus may be relevant for hippocampal disorders, since higher resting hippocampal blood flow is associated with better memory performance, although this relationship is not entirely clear. With its key role in learning and memory, the hippocampus is an important therapeutic target across multiple neuropsychiatric disorders including Alzheimer’s disease.

 

Read report here

 

Goodbody has no association with the organisation that conducted this research and is not in a position to validate the research methods, results or conclusions of the published article. It is provided for awareness of research available that may be of interest only. Any reader should read a range of articles and research to have a balanced and informed view.



Goodbody is a trading name of Goodbody Botanicals Ltd a member of the Goodbody Health Group.

Goodbody products are not intended to treat, diagnose, cure or prevent any disease. The information and products presented on this site are not intended for medical use nor do they make any medical claims. Always seek the advice of your physician or another qualified healthcare provider for any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health related program.

Copyright © 2021 Goodbody Botanicals Ltd

Company

Goodbody Botanicals Ltd
The Blue Building
Stubbs Lane
Beckington
BA11 6TE


* For further details about the Goodbody Health Group please click here