This review summarizes the chemical and biological effects of cannabidiol (CBD) and its natural and synthetic derivatives, particularly in relation to the antioxidant and anti-inflammatory effects of CBD and its derivatives, bearing in mind the possibilities of using this phytocannabinoid to protect against oxidative stress and the consequences associated with oxidative modifications of proteins and lipids.
It is believed that the endocannabinoid system, which includes G-protein coupled receptors and their endogenous lipid ligands, may be responsible for the therapeutic modulation of oxidative stress in various diseases. CBD has been shown to affect redox balance by modifying the level and activity of both oxidants and antioxidants. In this context, CBD is a promising molecule for pharmacotherapy. Important in CBD therapeutic applications is the lack of psychotropic effects. Furthermore, CBD is not teratogenic or mutagenic, and while CBD may interfere with the hepatic metabolism of some drugs by inactivating cytochrome P450 3A and P450 2C, and such interactions should be considered when co-administering CBD with other drugs metabolized by above enzymes, this does not discount the validity and antioxidant efficacy of CBD as a therapeutic for conditions stemming from oxidative stress and inflammation.
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