Cart

The Importance of the Endocannabinoid System (ECS) in Relation to Memory and PTSD Treatment

This study looks at conditions such as Post-Traumatic Stress Disorder (PTSD) as well as other conditions pertaining from fear, stress, and anxiety, through the targeting of Fatty Acid Amide Hydrolase (FAAH) to increase the efficiency of Anandamide’s (AEA) interactions with the ECS and different areas of the brain as a potential treatment for PTSD. Preclinical research shows that ECS activity influences functional connectivity between the prefrontal cortex and amygdala and thereby influences an organism’s ability to cope with threats and stressful experiences. Animal studies show that CB1 receptor activation within the amygdala is essential for extinction of fear memories. Failure to extinguish traumatic memories is a core symptom of PTSD, suggesting that potentiating ECS signalling may have a therapeutic potential in this condition.

This premise was to find potential alternative ways of targeting the ECS, as past medications (most notably rimonabant) that have been made available have been pulled due to adverse side-effects.

Analysis shows that, in contrast to other areas of neuropsychopharmacology, effects of endocannabinoid modulation on the regulation of fear and stress responses have so far translated from preclinical studies to humans. These effects are particularly encouraging in the context of PTSD treatment, as they target the core pathophysiological mechanisms of extinction-resistant fear and exaggerated stress responses, rather than merely mitigating symptoms.

 

Read report here

 

Goodbody has no association with the organisation that conducted this research and is not in a position to validate the research methods, results or conclusions of the published articleIt is provided for awareness of research available that may be of interest only. Any reader should read a range of articles and research to have a balanced and informed view.



Goodbody is a trading name of Goodbody Botanicals Ltd a member of the Sativa Wellness Group Inc.

Goodbody products are not intended to treat, diagnose, cure or prevent any disease. The information and products presented on this site are not intended for medical use nor do they make any medical claims. Always seek the advice of your physician or another qualified healthcare provider for any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health related program.

Copyright © 2021 Goodbody Botanicals Ltd

Company

Goodbody Botanicals Ltd
The Blue Building
Stubbs Lane
Beckington
BA11 6TE


* For further details about the Sativa Wellness Group please click here